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The European High Performance Computing Joint Undertaking (EuroHPC JU)

Investigation of novel epigenetic signals through combinatorial crosstalk between histone isoforms

32,000
Awarded Resources (in node hours)
MareNostrum5 ACC
System Partition
3 June 2024 - 2 June 2025
Allocation Period

AI Technology: Machine Learning, Vision (image recognition, image generation, text recognition OCR, etc.) 

 

Our genomic DNA is packed around highly conserved proteins known as histones which are also essential for the regulation of DNA templated processes such as gene expression and repair. Many of these diverse functions are executed via contextual cues beyond the DNA sequence spanning the field of epigenetics. 

Histone protein post-translational modifications (PTMs) have been an essential epigenetic process that regulates gene expression. The histone code is created by the fusion of different PTMs and regulates a range of biological processes. 

The goal of this study is to investigate how combinatorial histone isoforms might be used to encode new physiological signals. 

To uncover a potential new role for histone isoforms in cellular communication and the transduction of physiological signals, the project team aims to profile different cell types and tissues, examine their PTMs and how they relate to cellular functions, and perform transcriptomic and proteomic evaluations to clarify their effects on gene expression.