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The European High Performance Computing Joint Undertaking (EuroHPC JU)

Advancing Spatially Fractionated Radiotherapy

Awarded Resources (in core hours)
Vega CPU
System Partition
1 November 2022 - 31 October 2023
Allocation Period

Radiotherapy (RT) is one of the most frequently used methods for cancer treatment (above 50% of patients will receive RT).

Despite remarkable advancements, the normal tissues tolerances continue being the main limitation in RT, still compromising an efficient treatment of radioresistant tumors (i.e., gliomas) or paediatric cancers.

To overcome this limitation, the project proposes to explore new techniques based on novel dose delivery methods and different particle types. In this project, the goal is to advance in optimising the use of spatially fractionated radiation therapy (SFRT).

For that purpose, the project's team will work on adequate dosimetry protocols, including the determination of correction factors for high-resolution detectors. Additionally, they will work on the optimisation of the extraction system and beamline elements of cyclotron-based proton therapy centres to enable the generation of magnetically focused proton minibeams. Finally, the project will perform dosimetry studies of an optimised form of GRID therapy.

The small field sizes used and voxelised structures require important calculation resources. Only HPC will allow us to perform these calculations.